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Article

Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation.

European journal of immunology - 1 Jul 2016

Pohin Mathilde, Guesdon William, Mekouo Adela Andrine Tagne, Rabeony Hanitriniaina, Paris Isabelle, Atanassov Hristo, Favot Laure, Mcheik Jiad, Bernard François-Xavier, Richards Carl D, Amiaud Jérôme, Blanchard Frédéric, Lecron Jean-Claude, Morel Franck, Jégou Jean-François

Abstract excerpt

Oncostatin M (OSM) has been reported to be overexpressed in psoriasis skin lesions and to exert proinflammatory effects in vitro on human keratinocytes. Here, we report the proinflammatory role of OSM in vivo in a mouse model of skin inflammation induced by intradermal injection of murine OSM-encoding adenovirus (AdOSM) and compare with that induced by IL-6 injection. Here, we show that OSM potently regulates the...

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Source

Identifiers

PMID: 27122058
DOI: 10.1002/eji.201546216

Genes

OSM
CCL2
CCL20
CCL5
CXCL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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