Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral Replication

1 Jul 2011

Abstract excerpt

Compounds currently used for the treatment of HIV-1 Infections are targeted to viral proteins. However, the high intrinsic mutation and replication rates of HIV-1 often lead to the emergence of drug resistant strains and consequent therapeutic failure. On this basis, cellular cofactors represent attractive new targets for HIV-1 chemotherapy, since targeting a cellular factor that is required for viral replication...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRISPR and Genetic Engineering
Share to RNA Research and Splicing
Share to Viral Infections and Immunology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21651478
DOI: 10.2174/092986711796391688

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeting the Human DEAD-Box Polypeptide 3 (DDX3) RNA Helicase as a Novel Strategy to Inhibit Viral ReplicationPMID 21651478Read ↗

Human DDX3 protein is a valuable target to develop broad spectrum antiviral agentsSemantic proximity Read ↗

Viruses and the human DEAD-box helicase DDX3: inhibition or exploitation?Semantic proximity Read ↗

DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteinsSemantic proximity Read ↗

RNA Helicase DDX3: A Double-Edged Sword for Viral Replication and Immune SignalingSemantic proximity Read ↗

Unique Domain for a Unique Target: Selective Inhibitors of Host Cell DDX3X to Fight Emerging Viruses.Semantic proximity Read ↗

RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3XSemantic proximity Read ↗

RNA helicase DDX3: at the crossroad of viral replication and antiviral immunitySemantic proximity Read ↗

DDX3 DEAD-Box RNA Helicase Inhibits Hepatitis B Virus Reverse Transcription by Incorporation into NucleocapsidsSemantic proximity Read ↗

The ATP-Dependent RNA Helicase DDX3X Modulates Herpes Simplex Virus 1 Gene ExpressionSemantic proximity Read ↗

Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicasesSemantic proximity Read ↗

The DEAD-Box RNA Helicase DDX1 Interacts with the Viral Protein 3D and Inhibits Foot-and-Mouth Disease Virus ReplicationSemantic proximity Read ↗

DEAD-box RNA helicase DDX3X inhibits DENV replication via regulating type one interferon pathwaySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.