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The molecular weight and concentration of dextran sulfate affect cell growth and antibody production in CHO cell cultures

26 Apr 2016

Abstract excerpt

To investigate the effect of dextran sulfate (DS), a widely used anti-aggregation agent, on cell growth and monoclonal antibody (mAb) production including the quality attributes, DS with the three different MWs (4,000 Da, 15,000 Da, and 40,000 Da) at various concentrations (up to 1 g/L) was added to suspension cultures of two different recombinant CHO (rCHO) cell lines producing mAb, SM-0.025 and CS13-1.00. For...

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PMID: 27114230
DOI: 10.1002/btpr.2287

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