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Establishment and adipocyte differentiation of polycystic ovary syndrome‐derived induced pluripotent stem cells

24 Apr 2016

Abstract excerpt

OBJECTIVE: To establish a new biological cell model and approach to mimic abnormal lipid metabolism of polycystic ovary syndrome (PCOS) in vitro. MATERIALS AND METHODS: Epithelial cells from PCOS patients were reprogrammed to pluripotency by retroviral transduction using defined factors. Morphology, growth characteristics, karyotype, gene expression and differentiation in vitro and in vivo were detected by...

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PMID: 27108524
DOI: 10.1111/cpr.12258

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