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Article

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

10 Jun 2016

Abstract excerpt

The inflammasome NLRP3 is activated by pathogen associated molecular patterns (PAMPs) during infection, including RNA and proteins from influenza A virus (IAV). However, chronic activation by danger associated molecular patterns (DAMPs) can be deleterious to the host. We show that blocking NLRP3 activation can be either protective or detrimental at different stages of lethal influenza A virus (IAV)....

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PMID: 27283237
DOI: 10.1038/srep27912

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