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Article

miR-216b Targets FGFR1 and Confers Sensitivity to Radiotherapy in Pancreatic Ductal Adenocarcinoma Patients Without EGFR or KRAS Mutation.

Pancreas - 1 Oct 2016

Egeli Unal, Tezcan Gulcin, Cecener Gulsah, Tunca Berrin, Demirdogen Sevinc Elif, Kaya Ekrem, Ak Secil, Dundar Halit Ziya, Sarkut Pinar, Ugras Nesrin, Yerci Omer, Ozen Yilmaz, Evrensel Turkkan

Abstract excerpt

OBJECTIVES: The success of gemcitabine plus radiotherapy is dependent on the mutation status of pancreatic ductal adenocarcinoma (PDAC) tumors in the EGFR and KRAS genes; however, radiotherapy resistance may also be modulated epigenetically by microRNA (miRNA) regulation. In this study, we examined the potential effect of miRNAs on the resistance to radiotherapy in cases without EGFR or KRAS mutation. METHODS:...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, ras

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Source

Identifiers

PMID: 27101576
DOI: 10.1097/MPA.0000000000000640

Genes

EGFR
KRAS
FGFR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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