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Article

RAS-RAF-miR-296-3p signaling axis increases Rad18 expression to augment radioresistance in pancreatic and thyroid cancers.

Cancer letters - 1 Jun 2024

Wolfe Adam R, Feng Haihua, Zuniga Oscar, Rodrigues Henrique, Eldridge Daniel E, Yang Linlin, Shen Changxian, Williams Terence M

Abstract excerpt

Oncogenic RAS and RAF signaling has been implicated in contributing to radioresistance in pancreatic and thyroid cancers. In this study, we sought to better clarify molecular mechanisms contributing to this effect. We discovered that miRNA 296-3p (miR-296-3p) is significantly correlated with radiosensitivity in a panel of pancreatic cancer cells, and miR-296-3p is highly expressed in normal cells, but low in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38604313
DOI: 10.1016/j.canlet.2024.216873
PMCID: PMC11132429

Genes

RAD18
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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