Article
MicroRNA-218 inhibits cell invasion and migration of pancreatic cancer via regulating ROBO1.
Cancer biology & therapy - 1 Oct 2014
He Hang, Hao Si-Jie, Yao Lie, Yang Feng, Di Yang, Li Ji, Jiang Yong-Jian, Jin Chen, Fu De-Liang
Abstract excerpt
miRNA-218 is a highlighted tumor suppressor and its underlying role in tumor progression is still unknown. Here, we restored the expression of miRNA-218 in pancreatic cancer to clarify the function and potent downstream pathway of miRNA-218. The expressions of both miRNA-218 and its potent target gene ROBO1 were revealed by RT-PCR and western blotting analysis. Transfection of miRNA-218 precursor mimics and...
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