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Article

Time and tumor type (primary or metastatic) do not influence the detection of BRAF/NRAS mutations in formalin fixed paraffin embedded samples from melanomas.

Clinical chemistry and laboratory medicine - 1 Nov 2016

Potrony Miriam, Badenas Celia, Naerhuyzen Bénédicte, Aguilera Paula, Puig-Butille Joan Anton, Tell-Marti Gemma, Díaz Alba, Carrera Cristina, Alos Llucia, Delahaye Nicolas, Malvehy Josep, Puig Susana

Abstract excerpt

BACKGROUND: BRAF and NRAS mutation detection is crucial for advanced melanoma treatment. Our aim was to evaluate how different characteristics from formalin-fixed paraffin-embedded (FFPE) samples, age of the block or DNA concentration could influence the success of BRAF and NRAS mutational screening. METHODS: DNA was obtained from 144 FFPE samples (62 primary melanoma, 43 sentinel lymph nodes [SLN] and 39...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27101548
DOI: 10.1515/cclm-2015-1048

Genes

BRAF
NRAS
SLN

Provenance

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