Akkermansia muciniphila ameliorates colonic injury in mice with DSS-induced acute colitis by blocking macrophage pro-inflammatory phenotype switching via the HDAC5/DAB2 axis.

doi:10.1016/j.bbamcr.2024.119751

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Akkermansia muciniphila ameliorates colonic injury in mice with DSS-induced acute colitis by blocking macrophage pro-inflammatory phenotype switching via the HDAC5/DAB2 axis.

Biochimica et biophysica acta. Molecular cell research - 1 Oct 2024

Miao Yan, Wang Mian, Sun Hao, Zhang Yujie, Zhou Wei, Yang Wanli, Duan Lili, Niu Liaoran, Li Zhenshun, Chen Junfeng, Li Yiding, Fan Aqiang, Xie Qibin, Wei Siyu, Bai Han, Wang Chenyang, Chen Qian, Wang Xiangjie, Li Yunlong, Liu Jinqiang, Han Yu, Fan Daiming, Hong Liu

Abstract excerpt

Akkermansia muciniphila (A. muciniphila), a probiotic, has been linked to macrophage phenotypic polarization in different diseases. However, the role and mechanisms of A. muciniphila in regulating macrophage during ulcerative colitis (UC) are not clear. This research aimed to examine the impact of A. muciniphila on dextran sulfate sodium (DSS)-induced acute colitis and elucidate the underlying mechanism related...

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PMID: 38776988
DOI: 10.1016/j.bbamcr.2024.119751

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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