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JAK2 inhibitor CEP-33779 prevents mouse oocyte maturation in vitro

15 Jun 2017

Abstract excerpt

The inhibitor CEP-33779 is a specific selective inhibitor of Janus kinase 2 (JAK2). In most somatic cells, JAK2 plays essential roles in cellular signal transduction and in the regulation of cell cycle. Little is known regarding the effects of JAK2 on mammalian oocyte maturation. In the present study, we investigated the effects of CEP-33779 on mouse oocytes' meiosis and the possible mechanisms of JAK2 during...

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PMID: 28615348
DOI: 10.1042/bsr20170642

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