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Article

Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility.

American journal of human genetics - 5 Apr 2018

Sang Qing, Li Bin, Kuang Yanping, Wang Xueqian, Zhang Zhihua, Chen Biaobang, Wu Ling, Lyu Qifeng, Fu Yonglun, Yan Zheng, Mao Xiaoyan, Xu Yao, Mu Jian, Li Qiaoli, Jin Li, He Lin, Wang Lei

Abstract excerpt

Fertilization is a fundamental process of development and is a prerequisite for successful human reproduction. In mice, although several receptor proteins have been shown to play important roles in the process of fertilization, only three genes have been shown to cause fertilization failure and infertility when deleted in vivo. In clinical practice, some infertility case subjects suffer from recurrent failure of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29606300
DOI: 10.1016/j.ajhg.2018.02.015
PMCID: PMC5985286

Genes

WEE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Homozygous Mutations in WEE2 Cause Fertilization Failure and Female Infertility.PMID 29606300Read ↗

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Novel mutations in WEE2: Expanding the spectrum of mutations responsible for human fertilization failureSemantic proximity Read ↗

Novel WEE2 homozygous mutations c.1346C>T and c.949A>T identified in primary infertile women due to unexplained fertilization failure.Semantic proximity Read ↗

Novel compound heterozygous mutations in WEE2 causes female infertility and fertilization failureSemantic proximity Read ↗

Novel compound heterozygous mutation in WEE2 is associated with fertilization failure: case report of an infertile woman and literature review.Semantic proximity Read ↗

A Novel Homozygous Missense Mutation of WEE2 Causes Female Infertility Characterized by Fertilization FailureSemantic proximity Read ↗

Oocyte-specific Wee1-like protein kinase 2 is dispensable for fertility in miceSemantic proximity Read ↗

Novel WEE2 gene variants identified in patients with fertilization failure and female infertilitySemantic proximity Read ↗

Curriculum Vitae of WEE2 Kinase in Homeostasis and Diseases: A Systematic Review.Semantic proximity Read ↗

New biallelic mutations in WEE2: expanding the spectrum of mutations that cause fertilization failure or poor fertilizationSemantic proximity Read ↗

Homozygous missense mutation Arg207Cys in the WEE2 gene causes female infertility and fertilization failureSemantic proximity Read ↗

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