Article
Multiplex Minisequencing of the HBB Gene: A Rapid Strategy to Confirm the Most Frequent β-Thalassemia Mutations in the Tunisian Population.
Hemoglobin - 1 Jan 2015
Ben Charfeddine Ilhem, Ben Lazreg Taheni, M'sakni Ahlem, Amara Abdelbasset, Mlika Adnène, Chaïeb Anouar, Hlel Khalid, Zouari Noura, Zbidi Faïza, Bouguila Jihène, Soyah Najla, Ayedi Abdelkarim, Ben Hamouda Hechmi, Abroug Saoussen, Boughamoura Lamia, Saad Ali, Gribaa Moez
Abstract excerpt
The β hemoglobinopathies [β-thalassemia (β-thal) and structural hemoglobin (Hb) variants such as Hb S (HBB: c.20A > T) and Hb E (HBB: c.79G > A)] are among the most common inherited diseases worldwide. In Tunisia, due to the high prevalence of consanguineous marriages, the recurrent risk of this disease is high. The average prevalence of hemoglobinopathies is 4.48%, reaching 12.50% in some focus regions. The...
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