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Article

Induction of integrin β3 by sustained ERK activity promotes the invasiveness of TGFβ-induced mesenchymal tumor cells.

Cancer letters - 1 Jul 2016

Hong Soon-Ki, Park Jeong-Rak, Kwon Ok-Seon, Kim Keun-Tae, Bae Gab-Yong, Cha Hyuk-Jin

Abstract excerpt

The emerging roles of integrin β3 in the epithelial-mesenchymal transition (EMT) and drug resistance underline its significance in cancer metastasis and recurrence. However, the molecular mechanism underlying the distinctive expression of integrin β3 is less understood. In the present report, we demonstrated that repetitive exposure to transforming growth factor β (TGFβ), a potent inducer of the EMT,...

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Source

Identifiers

PMID: 27085460
DOI: 10.1016/j.canlet.2016.04.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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