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Article

Identification of integrin α3 as a molecular marker of cells undergoing epithelial-mesenchymal transition and of cancer cells with aggressive phenotypes.

Cancer science - 1 Sept 2013

Shirakihara Takuya, Kawasaki Tomonori, Fukagawa Akihiko, Semba Kentaro, Sakai Ryuichi, Miyazono Kohei, Miyazawa Keiji, Saitoh Masao

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is a crucial event in wound healing, tissue repair, and cancer progression in adult tissues. Transforming growth factor (TGF)-β induces EMT in mouse epithelial cells. During prolonged treatment, TGF-β successively induces myofibroblastic differentiation with increased expression of myofibroblast marker proteins, including smooth muscle α actin and calponin. We recently...

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Identifiers

PMID: 23786209
DOI: 10.1111/cas.12220
PMCID: PMC7656537

Genes

ITGA3

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