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Article

MicroRNA-19a/b-3p protect the heart from hypertension-induced pathological cardiac hypertrophy through PDE5A

17 Apr 2018

Abstract excerpt

AIM: PDE5A is a leading factor contributing to cGMP signaling and cardiac hypertrophy. However, microRNA-mediated posttranscriptional regulation of PDE5A has not been reported. The aim of this study is to screen the microRNAs that are able to regulate PDE5A and explore the function of the microRNAs in cardiac hypertrophy and remodeling. METHODS AND RESULTS: Although miR-19a/b-3p (microRNA-19a-3p and...

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Share to Cardiac Fibrosis and Remodeling
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PMID: 29664809
DOI: 10.1097/hjh.0000000000001769

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