Article
GRN and MAPT Mutations in 2 Frontotemporal Dementia Research Centers in Brazil.
Alzheimer disease and associated disorders - 1 Jan 2000
Takada Leonel T, Bahia Valeria S, Guimarães Henrique C, Costa Thais V M M, Vale Thiago C, Rodriguez Roberta D, Porto Fabio H G, Machado João C B, Beato Rogério G, Cesar Karolina G, Smid Jerusa, Nascimento Camila F, Grinberg Lea T, Brucki Sonia M D, Maximino Jessica R, Camargos Sarah T, Chadi Gerson, Caramelli Paulo, Nitrini Ricardo
Abstract excerpt
BACKGROUND: Mutations in GRN (progranulin) and MAPT (microtubule-associated protein tau) are among the most frequent causes of monogenic frontotemporal dementia (FTD), but data on the frequency of these mutations in regions such as Latin America are still lacking. OBJECTIVE: We aimed to investigate the frequencies of GRN and MAPT mutations in FTD cohorts from 2 Brazilian dementia research centers, the University...
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