Article
Autosomal Dominant Frontotemporal Lobar Degeneration in a Filipino Family with Progranulin Mutation.
Dementia and geriatric cognitive disorders - 1 Jan 2020
Dominguez Jacqueline, Ng Arlene, Yu Jeryl, Guevarra Anne Cristine, Daroy Maria Luisa, Alfon Alicia, Catindig Joseree-Ann, Dizon Mercedes, Santiago Jonas, Del Moral Maria Clarissa, Yu Justine, Jamerlan Angelo, Ligsay Antonio, Bagyinszky Eva, An Seong Soo, Kim Sangyun
Abstract excerpt
BACKGROUND: Compared to Western populations, familial frontotemporal lobar degeneration (FTLD) is rare among Asians. Progranulin (GRN) gene mutation, which is a major cause of FTLD, is likewise rare. We present a family with FTLD from the Philippines with an autosomal dominant pattern of inheritance and GRN mutation and briefly review reports of GRN mutations in Asia. CASE PRESENTATION: The proband is 66 years...
Topics
- Aged
- Female
- Frontotemporal Dementia
- Frontotemporal Lobar Degeneration
- Humans
- Mutation
- Philippines
- Progranulins