Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dominant frontotemporal dementia mutations in 140 cases of primary progressive aphasia and speech apraxia.

Dementia and geriatric cognitive disorders - 1 Jan 2015

Flanagan Eoin P, Baker Matthew C, Perkerson Ralph B, Duffy Joseph R, Strand Edythe A, Whitwell Jennifer L, Machulda Mary M, Rademakers Rosa, Josephs Keith A

Abstract excerpt

BACKGROUND: Mutations in three genes [chromosome 9 open-reading-frame 72 (C9ORF72); microtubule-associated protein tau (MAPT) and progranulin (GRN)] account for the vast majority of familial, and a proportion of sporadic, frontotemporal dementia (FTD) cases. Progressive apraxia of speech (PAOS) is a type of FTD characterized by speech production deficits without a known cause. METHODS: We therefore assessed for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aphasia, Primary Progressive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apraxias

Share to C9orf72 Protein

Share to Frontotemporal Dementia

Share to Intercellular Signaling Peptides and Proteins

Share to Progranulins

Share to tau Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25765123
DOI: 10.1159/000375299
PMCID: PMC4879710

Genes

GRN
MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dominant frontotemporal dementia mutations in 140 cases of primary progressive aphasia and speech apraxia.PMID 25765123Read ↗

Distinct clinical characteristics of C9orf72 expansion carriers compared with GRN, MAPT, and nonmutation carriers in a Flanders-Belgian FTLD cohort.Semantic proximity Read ↗

Genetic screen in a large series of patients with primary progressive aphasiaSemantic proximity Read ↗

Primary Progressive Aphasia Associated With GRN Mutations: New Insights Into the Nonamyloid Logopenic Variant.Semantic proximity Read ↗

Classification of primary progressive aphasia: challenges and complexitiesSemantic proximity Read ↗

GRN and MAPT Mutations in 2 Frontotemporal Dementia Research Centers in Brazil.Semantic proximity Read ↗

Primary progressive aphasia: six questions in search of an answer.Semantic proximity Read ↗

Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations.Semantic proximity Read ↗

Phenotypic signatures of genetic frontotemporal dementia.Semantic proximity Read ↗

Clinical and pathological features of familial frontotemporal dementia caused by C9ORF72 mutation on chromosome 9p.Semantic proximity Read ↗

Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72Semantic proximity Read ↗

Motor Speech Phenotypes of Frontotemporal Dementia, Primary Progressive Aphasia, and Progressive Apraxia of Speech.Semantic proximity Read ↗

Incorporating new diagnostic schemas, genetics, and proteinopathy into the evaluation of frontotemporal degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.