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Article

Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia.

Brain : a journal of neurology - 1 Nov 2006

Snowden J S, Pickering-Brown S M, Mackenzie I R, Richardson A M T, Varma A, Neary D, Mann D M A

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) refers to a focal, non-Alzheimer form of cerebral degeneration that encompasses the distinct clinical syndromes of frontotemporal dementia (FTD), progressive non-fluent aphasia (PNFA) and semantic dementia. Some patients show tau-based pathological changes and in familial cases mutations have been identified in the microtubule-associated protein tau gene (MAPT) on...

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Identifiers

PMID: 17003069
DOI: 10.1093/brain/awl267

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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