Generation of Hypertension-Associated STK39 Polymorphism Knockin Cell Lines With the Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 System.

doi:10.1161/HYPERTENSIONAHA.115.05872

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Article

Generation of Hypertension-Associated STK39 Polymorphism Knockin Cell Lines With the Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 System.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2015

Mandai Shintaro, Mori Takayasu, Sohara Eisei, Rai Tatemitsu, Uchida Shinichi

Abstract excerpt

Previous genome-wide association studies identified serine threonine kinase 39 (STK39), encoding STE20/SPS1-related proline/alanine-rich kinase, as one of a limited number of hypertension susceptibility genes. A recent meta-analysis confirmed the association of STK39 intronic polymorphism rs3754777 with essential hypertension, among previously reported hypertension-associated STK39 polymorphisms. However, the...

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PMID: 26416847
DOI: 10.1161/HYPERTENSIONAHA.115.05872

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STK39

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