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Article

Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains.

Journal of thrombosis and haemostasis : JTH - 1 Aug 2016

Szabo R, Samson A L, Lawrence D A, Medcalf R L, Bugge T H

Abstract excerpt

UNLABELLED: Essentials C57BL/6J-tissue plasminogen activator (tPA)-deficient mice are widely used to study tPA function. Congenic C57BL/6J-tPA-deficient mice harbor large 129-derived chromosomal segments. The 129-derived chromosomal segments contain gene mutations that may confound data interpretation. Passenger mutation-free isogenic tPA-deficient mice were generated for study of tPA function. SUMMARY:...

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PMID: 27079292
DOI: 10.1111/jth.13338
PMCID: PMC5322813

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PLAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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