Article
Genetic polymorphism of murine tissue plasminogen activator associated with antiphospholipid syndrome.
Genes and immunity - 1 Nov 1999
Shirai J, Ida A, Jiang Y, Sanokawa-Akakura R, Miura Y, Yan K, Hamano Y, Hirose S, Shirai T
Abstract excerpt
In a subset of patients with systemic lupus erythematosus (SLE), antiphospholipid syndrome characterized by thrombocytopenia, thrombosis, recurrent abortion and antiphospholipid antibodies develops. Male (NZW x BXSB) F1 mice are widely used as a model for SLE-associated antiphospholipid syndrome. Our earlier genetic studies showed that one susceptibility allele for thrombocytopenia and associated IgG...
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