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Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.

Immunity - 21 Jul 2015

Vanden Berghe Tom, Hulpiau Paco, Martens Liesbet, Vandenbroucke Roosmarijn E, Van Wonterghem Elien, Perry Seth W, Bruggeman Inge, Divert Tatyana, Choi Sze Men, Vuylsteke Marnik, Shestopalov Valery I, Libert Claude, Vandenabeele Peter

Abstract excerpt

Targeted mutagenesis in mice is a powerful tool for functional analysis of genes. However, genetic variation between embryonic stem cells (ESCs) used for targeting (previously almost exclusively 129-derived) and recipient strains (often C57BL/6J) typically results in congenic mice in which the ta...

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Identifiers

PMID: 26163370
DOI: 10.1016/j.immuni.2015.06.011
PMCID: PMC4800811

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26163370-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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