Article
Genetic mapping of putative Chrna7 and Luzp2 neuronal transcriptional enhancers due to impact of a transgene-insertion and 6.8 Mb deletion in a mouse model of Prader-Willi and Angelman syndromes.
BMC genomics - 9 Nov 2005
Stefan Mihaela, Claiborn Kathryn C, Stasiek Edyta, Chai Jing-Hua, Ohta Tohru, Longnecker Richard, Greally John M, Nicholls Robert D
Abstract excerpt
BACKGROUND: Prader-Willi and Angelman syndrome (PWS and AS) patients typically have an approximately 5 Mb deletion of human chromosome 15q11-q13, of opposite parental origin. A mouse model of PWS and AS has a transgenic insertion-deletion (TgPWS/TgAS) of chromosome 7B/C subsequent to paternal or maternal inheritance, respectively. In this study, we define the deletion endpoints and examine the impact on...
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