Article
Among a panel of polymorphisms in genes related to oxidative stress, CAT-262 C>T, GPX1 Pro198Leu and GSTP1 Ile105Val influence the risk of developing BCR-ABL negative myeloproliferative neoplasms.
Hematology (Amsterdam, Netherlands) - 1 Oct 2016
Trifa Adrian P, Bănescu Claudia, Dima Delia, Bojan Anca S, Tevet Mihaela, Moldovan Valeriu G, Vesa Ștefan C, Murat Meilin, Pop Ioan V, Skrypnyk Cristina, Popp Radu A
Abstract excerpt
OBJECTIVES: To analyze the relationship between six polymorphisms in genes related to oxidative stress, namely CAT-262 C>T, MnSOD Ala16Val, GPX1 Pro198Leu, GSTM1 and GSTT1 null genotypes, and GSTP1 Ile105Val, and the occurrence of BCR-ABL negative myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, and primary myelofibrosis). METHODS: We genotyped for these polymorphisms 328 patients with...
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