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Article

From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia.

Oxidative medicine and cellular longevity - 1 Jan 2016

Bănescu Claudia, Iancu Mihaela, Trifa Adrian P, Cândea Marcela, Benedek Lazar Erzsebet, Moldovan Valeriu G, Duicu Carmen, Tripon Florin, Crauciuc Andrei, Dobreanu Minodora

Abstract excerpt

Oxidative stress might contribute to the occurrence of cancers, including the hematological ones. Various genetic polymorphisms were shown to increase the quantity of reactive oxygen species, a phenomenon that is able to induce mutations and thus promote cancers. The purpose of the study was to evaluate the association between CAT C262T, GPX1 Pro198Leu, MnSOD Ala16Val, GSTM1, GSTT1, and GSTP1 Ile105Val gene...

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Source

Open in PubMed Open full text

Identifiers

PMID: 26823947
DOI: 10.1155/2016/2536705
PMCID: PMC4707325

Genes

GSTP1
GPX1
CAT
GSTM1
GSTT1
FLT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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From Six Gene Polymorphisms of the Antioxidant System, Only GPX Pro198Leu and GSTP1 Ile105Val Modulate the Risk of Acute Myeloid Leukemia.PMID 26823947Read ↗

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Among a panel of polymorphisms in genes related to oxidative stress, CAT-262 C>T, GPX1 Pro198Leu and GSTP1 Ile105Val influence the risk of developing BCR-ABL negative myeloproliferative neoplasms.Semantic proximity Read ↗

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