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Article

Does Choice Matter? Reference-Based Alignment for Molecular Epidemiology of Tuberculosis.

Journal of clinical microbiology - 1 Jul 2016

Lee Robyn S, Behr Marcel A

Abstract excerpt

When using genome sequencing for molecular epidemiology, short sequence reads are aligned to an arbitrary reference strain to detect single nucleotide polymorphisms. We investigated whether reference genome selection influences epidemiological inferences of Mycobacterium tuberculosis transmission by aligning sequence reads from 162 closely related lineage 4 (Euro-American) isolates to 7 different genomes....

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Share to Genome, Bacterial
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 27076659
DOI: 10.1128/JCM.00364-16
PMCID: PMC4922084

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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