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Article

Reciprocal stimulation of pancreatic acinar and stellate cells in a novel long-term in vitro co-culture model.

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Jan 2000

Bläuer Merja, Laaninen Matias, Sand Juhani, Laukkarinen Johanna

Abstract excerpt

BACKGROUND/OBJECTIVES: Pancreatic stellate cells (PSCs) are the key fibrogenic cells in the pancreas. Acinar cell injury is known to trigger PSC activation. To facilitate the experimental analysis of the crosstalk between acinar cells and PSCs, an in vitro system for their long-term co-cultivation was developed. MATERIALS AND METHODS: PSCs and acinar cells capable of retaining their secretory phenotype in...

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Identifiers

PMID: 27075041
DOI: 10.1016/j.pan.2016.03.012

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HMGB1

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