Article
In Vitro Drug Sensitivity Tests to Predict Molecular Target Drug Responses in Surgically Resected Lung Cancer.
PloS one - 1 Jan 2016
Miyazaki Ryohei, Anayama Takashi, Hirohashi Kentaro, Okada Hironobu, Kume Motohiko, Orihashi Kazumasa
Abstract excerpt
BACKGROUND: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) and anaplastic lymphoma kinase (ALK) inhibitors have dramatically changed the strategy of medical treatment of lung cancer. Patients should be screened for the presence of the EGFR mutation or echinoderm microtubule-associated protein-like 4 (EML4)-ALK fusion gene prior to chemotherapy to predict their clinical response. The...
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