Article
Associations between driver gene mutations and cytotoxic chemosensitivity in patients with non-small cell lung cancer.
Anticancer research - 1 Mar 2015
Morodomi Yosuke, Okamoto Tatsuro, Kohno Mikihiro, Katsura Masakazu, Takada Kazuki, Suzuki Yuzo, Fujishita Takatoshi, Kitahara Hirokazu, Shimamatsu Shinichiro, Yoshida Tsukihisa, Tagawa Tetsuzo, Okano Shinji, Maehara Yoshihiko
Abstract excerpt
BACKGROUND/AIM: Patients with non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) gene mutations or echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase (EML4-ALK) rearrangement often have a better prognosis when they are treated with specific inhibitors than when treated with cytotoxic agents. However, the associations between gene mutations and cytotoxic...
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