Article
MicroRNA 139-5p coordinates APLNR-CXCR4 crosstalk during vascular maturation.
Nature communications - 12 Apr 2016
Papangeli Irinna, Kim Jongmin, Maier Inna, Park Saejeong, Lee Aram, Kang Yujung, Tanaka Keiichiro, Khan Omar F, Ju Hyekyung, Kojima Yoko, Red-Horse Kristy, Anderson Daniel G, Siekmann Arndt F, Chun Hyung J
Abstract excerpt
G protein-coupled receptor (GPCR) signalling, including that involving apelin (APLN) and its receptor APLNR, is known to be important in vascular development. How this ligand-receptor pair regulates the downstream signalling cascades in this context remains poorly understood. Here, we show that mice with Apln, Aplnr or endothelial-specific Aplnr deletion develop profound retinal vascular defects, which are at...
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