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Article

Adrenomedullin signaling is necessary for murine lymphatic vascular development

20 Dec 2007

Abstract excerpt

The lymphatic vascular system mediates fluid homeostasis, immune defense, and tumor metastasis. Only a handful of genes are known to affect the development of the lymphatic vasculature, and even fewer represent therapeutic targets for lymphatic diseases. Adrenomedullin (AM) is a multifunctional peptide vasodilator that transduces its effects through the calcitonin receptor-like receptor (calcrl) when the receptor...

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PMID: 18097475
DOI: 10.1172/jci33302

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