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Article

Addiction of Hypertransformable Pneumococcal Isolates to Natural Transformation for In Vivo Fitness and Virulence.

Infection and immunity - 1 Jun 2016

Li Guiling, Liang Zhuowen, Wang Xiatai, Yang Yonghong, Shao Zhujun, Li Machao, Ma Yueyun, Qu Fen, Morrison Donald A, Zhang Jing-Ren

Abstract excerpt

Natural genetic transformation of Streptococcus pneumoniae, an important human pathogen, mediates horizontal gene transfer for the development of drug resistance, modulation of carriage and virulence traits, and evasion of host immunity. Transformation frequency differs greatly among pneumococcal clinical isolates, but the molecular basis and biological importance of this interstrain variability remain unclear....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27068094
DOI: 10.1128/IAI.00097-16
PMCID: PMC4907133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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