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Article

Antibiotic Stress Induces Genetic Transformability in the Human Pathogen Streptococcus pneumoniae

6 Jul 2006

Abstract excerpt

Natural transformation is a widespread mechanism for genetic exchange in bacteria. Aminoglycoside and fluoroquinolone antibiotics, as well as mitomycin C, a DNA-damaging agent, induced transformation in Streptococcus pneumoniae. This induction required an intact competence regulatory cascade. Furthermore, mitomycin C induction of recA was strictly dependent on the development of competence. In response to...

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PMID: 16825569
DOI: 10.1126/science.1127912

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