Article
Identification and analysis of fitness of resistance mutations against the HCV protease inhibitor SCH 503034.
Antiviral research - 1 Jun 2006
Tong Xiao, Chase Robert, Skelton Angela, Chen Tong, Wright-Minogue Jackie, Malcolm Bruce A
Abstract excerpt
HCV NS3 protease variants resistant to the protease inhibitor SCH 503034 were selected. Three mutations, T54A, V170A and A156S mutations conferred low to moderate levels of resistance (<20-fold). Longer exposure (>10 passages) or selection with higher levels of compound led to the selection of a more resistant variant, A156T (>100-fold). [Lin, C., Lin, K., Luong, Y.P., Rao, B.G., Wei, Y.Y., Brennan, D.L.,...
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