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Article

Calpain 3 is a modulator of the dysferlin protein complex in skeletal muscle

11 Mar 2008

Abstract excerpt

Muscular dystrophies comprise a genetically heterogeneous group of degenerative muscle disorders characterized by progressive muscle wasting and weakness. Two forms of limb-girdle muscular dystrophy, 2A and 2B, are caused by mutations in calpain 3 (CAPN3) and dysferlin (DYSF), respectively. While CAPN3 may be involved in sarcomere remodeling, DYSF is proposed to play a role in membrane repair. The coexistence of...

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PMID: 18334579
DOI: 10.1093/hmg/ddn081

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