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Article

Genetic modulation of the interleukin 6 (IL-6) system in patients with advanced gastric cancer: a background for an alternative target therapy.

BMC cancer - 22 May 2014

Ruzzo Annamaria, Catalano Vincenzo, Canestrari Emanuele, Giacomini Elisa, Santini Daniele, Tonini Giuseppe, Vincenzi Bruno, Fiorentini Giammaria, Magnani Mauro, Graziano Francesco

Abstract excerpt

BACKGROUND: IL-6 triggers oncogenic/angiogenic signals and the cytokine-dependent pro-cachexia cascade. The prognostic role of the functional IL-6 (promoter) rs1800795 and the IL-6R (receptor) rs8192284 single nucleotide polymorphisms (SNP) was studied in patients with advanced gastric cancer treated with palliative chemotherapy. METHODS: One-hundred-sixty-one patients were genotyped for rs1800795 and rs8192284...

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Identifiers

PMID: 24886605
DOI: 10.1186/1471-2407-14-357
PMCID: PMC4046495

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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