Some pitfalls in application of functional data analysis approach to association studies.

Abstract excerpt

One of the most effective methods for gene-based mapping employs functional data analysis, which smoothes data using standard basis functions. The full functional linear model includes a functional representation of genotypes and their effects, while the beta-smooth only model smoothes the genotype effects only. Benefits and limitations of the beta-smooth only model should be studied before using it in practice....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Computer Simulation
• Share to Genetic Association Studies
• Share to Genotype