DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis.

doi:10.1016/j.jaci.2015.12.1341

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Article

DNA methylation within melatonin receptor 1A (MTNR1A) mediates paternally transmitted genetic variant effect on asthma plus rhinitis.

The Journal of allergy and clinical immunology - 1 Sept 2016

Sarnowski Chloé, Laprise Catherine, Malerba Giovanni, Moffatt Miriam F, Dizier Marie-Hélène, Morin Andréanne, Vincent Quentin B, Rohde Klaus, Esparza-Gordillo Jorge, Margaritte-Jeannin Patricia, Liang Liming, Lee Young-Ae, Bousquet Jean, Siroux Valérie, Pignatti Pier Franco, Cookson William O, Lathrop Mark, Pastinen Tomi, Demenais Florence, Bouzigon Emmanuelle

Abstract excerpt

BACKGROUND: Asthma and allergic rhinitis (AR) are common allergic comorbidities with a strong genetic component in which epigenetic mechanisms might be involved. OBJECTIVE: We aimed to identify novel risk loci for asthma and AR while accounting for parent-of-origin effect. METHODS: We performed a series of genetic analyses, taking into account the parent-of-origin effect in families ascertained through asthma:...

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PMID: 27038909
DOI: 10.1016/j.jaci.2015.12.1341

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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