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Article

Do founder mutations characteristic of some cancer sites also predispose to pancreatic cancer?

International journal of cancer - 1 Aug 2016

Lener Marcin R, Scott Rodney J, Kluźniak Wojciech, Baszuk Piotr, Cybulski Cezary, Wiechowska-Kozłowska Anna, Huzarski Tomasz, Byrski Tomasz, Kładny Józef, Pietrzak Sandra, Soluch Agnieszka, Jakubowska Anna, Lubiński Jan

Abstract excerpt

Understanding of the etiology and risk of pancreatic cancer (PaCa) is still poorly understood. This study evaluated the prevalence of 10 Polish founder mutations in four genes among PaCa patients and assessed their possible association with the risk of disease in Poland. In the study 383 PaCa patients and 4,000 control subjects were genotyped for founder mutations in: BRCA1 (5382insC, 4153delA, C61G), CHEK2...

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Source

Identifiers

PMID: 27038244
DOI: 10.1002/ijc.30116

Genes

BRCA1
CHEK2
PALB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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