Article
Capsules of virulent pneumococcal serotypes enhance formation of neutrophil extracellular traps during in vivo pathogenesis of pneumonia.
Oncotarget - 12 Apr 2016
Moorthy Anandi Narayana, Rai Prashant, Jiao Huipeng, Wang Shi, Tan Kong Bing, Qin Liang, Watanabe Hiroshi, Zhang Yongliang, Teluguakula Narasaraju, Chow Vincent Tak Kwong
Abstract excerpt
Neutrophil extracellular traps (NETs) are released by activated neutrophils to ensnare and kill microorganisms. NETs have been implicated in tissue injury since they carry cytotoxic components of the activated neutrophils. We have previously demonstrated the generation of NETs in infected murine lungs during both primary pneumococcal pneumonia and secondary pneumococcal pneumonia after primary influenza. In this...
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