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Article

Group A Streptococcus establishes pharynx infection by degrading the deoxyribonucleic acid of neutrophil extracellular traps.

Scientific reports - 24 Feb 2020

Tanaka Mototsugu, Kinoshita-Daitoku Ryo, Kiga Kotaro, Sanada Takahito, Zhu Bo, Okano Tokuju, Aikawa Chihiro, Iida Tamako, Ogura Yoshitoshi, Hayashi Tetsuya, Okubo Koshu, Kurosawa Miho, Hirahashi Junichi, Suzuki Toshihiko, Nakagawa Ichiro, Nangaku Masaomi, Mimuro Hitomi

Abstract excerpt

Group A Streptococcus (GAS) secretes deoxyribonucleases and evades neutrophil extracellular killing by degrading neutrophil extracellular traps (NETs). However, limited information is currently available on the interaction between GAS and NETs in the pathogenicity of GAS pharyngitis. In this study, we modified a mouse model of GAS pharyngitis and revealed an essential role for DNase in this model. After...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32094510
DOI: 10.1038/s41598-020-60306-w
PMCID: PMC7039874

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