Article
Artesunate-Amodiaquine and Artemether-Lumefantrine Therapies and Selection of Pfcrt and Pfmdr1 Alleles in Nanoro, Burkina Faso.
PloS one - 1 Jan 2016
Sondo Paul, Derra Karim, Diallo Nakanabo Seydou, Tarnagda Zekiba, Kazienga Adama, Zampa Odile, Valéa Innocent, Sorgho Hermann, Owusu-Dabo Ellis, Ouédraogo Jean-Bosco, Guiguemdé Tinga Robert, Tinto Halidou
Abstract excerpt
The adoption of Artemisinin based combination therapies (ACT) constitutes a basic strategy for malaria control in sub-Saharan Africa. Moreover, since cases of ACT resistance have been reported in South-East Asia, the need to understand P. falciparum resistance mechanism to ACT has become a global research goal. The selective pressure of ACT and the possibility that some specific Pfcrt and Pfmdr1 alleles are...
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