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Article

Different patterns of pfcrt and pfmdr1 polymorphisms in P. falciparum isolates from Nigeria and Brazil: the potential role of antimalarial drug selection pressure.

The American journal of tropical medicine and hygiene - 1 Feb 2012

Gbotosho Grace O, Folarin Onikepe A, Bustamante Carolina, da Silva Luis Hildebrando Pereira, Mesquita Elieth, Sowunmi Akintunde, Zalis Mariano G, Oduola Ayoade M J, Happi Christian T

Abstract excerpt

The effect of antimalarial drug selection on pfcrt and pfmdr1 polymorphisms in Plasmodium falciparum isolates from two distinct geographical locations was determined in 70 and 18 P. falciparum isolates from Nigeria and Brazil, respectively, using nested polymerase chain reaction and direct DNA sequencing approaches. All isolates from Brazil and 72% from Nigeria harbored the mutant SVMNT and CVIET pfcrt haplotype,...

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Identifiers

PMID: 22302850
DOI: 10.4269/ajtmh.2012.11-0368
PMCID: PMC3269269

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Source receipt: pubmed, retrieved 7 Sept 2026.

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