Article
Venezuelan Equine Encephalitis Virus nsP3 Phosphorylation Can Be Mediated by IKKβ Kinase Activity and Abrogation of Phosphorylation Inhibits Negative-Strand Synthesis.
Viruses - 13 Sept 2020
Bakovic Allison, Bhalla Nishank, Kortchak Stephanie, Sun Chengqun, Zhou Weidong, Ahmed Aslaa, Risner Kenneth, Klimstra William B, Narayanan Aarthi
Abstract excerpt
Venezuelan equine encephalitis virus (VEEV), a mosquito transmitted alphavirus of the Togaviridae family, can cause a highly inflammatory and encephalitic disease upon infection. Although a category B select agent, no FDA-approved vaccines or therapeutics against VEEV currently exist. We previously demonstrated NF-κB activation and macromolecular reorganization of the IKK complex upon VEEV infection in vitro,...
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