Article
[Hypothetical SNP Markers That Significantly Affect the Affinity of the TATA-Binding Protein to VEGFA, ERBB2, IGF1R, FLT1, KDR, and MET Oncogene Promoters as Chemotherapy Targets].
Molekuliarnaia biologiia - 1 Jan 2000
Turnaev I I, Rasskazov D A, Arkova O V, Ponomarenko M P, Ponomarenko P M, Savinkova L K, Kolchanov N A
Abstract excerpt
The following hypothesis has been proposed: IF an SNP can significantly increase the expression of an oncogene by increasing the affinity of the TATA-binding protein (TBP) to its promoter, THEN this SNP can also reduce the apparent bioactivity of inhibitors of this oncogene during antitumor chemotherapy and vice versa. In the context of this hypothesis, the previously proposed method (http://beehive.bionet.nsc....
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