Article
Rapamycin-Induced Hypoxia Inducible Factor 2A Is Essential for Chondrogenic Differentiation of Amniotic Fluid Stem Cells.
Stem cells translational medicine - 1 May 2016
Preitschopf Andrea, Schörghofer David, Kinslechner Katharina, Schütz Birgit, Zwickl Hannes, Rosner Margit, Joó József Gabor, Nehrer Stefan, Hengstschläger Markus, Mikula Mario
Abstract excerpt
UNLABELLED: Amniotic fluid stem (AFS) cells represent a major source of donor cells for cartilage repair. Recently, it became clear that mammalian target of rapamycin (mTOR) inhibition has beneficial effects on cartilage homeostasis, but the effect of mTOR on chondrogenic differentiation is still elusive. Therefore, the objectives of this study were to investigate the effects of mammalian target of rapamycin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.