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Article

Enhanced chondrogenesis from human embryonic stem cells

9 Jul 2019

Abstract excerpt

Human embryonic stem cells (hESCs) have great potential for the repair of damaged articular cartilage. We developed a serum-free 14-day protocol for hESC differentiation into chondrocyte progenitors, which surprisingly lacked strong cartilage matrix production in in vitro tests. In order to direct these progenitors to a more mature phenotype, we investigated substituting different members of the TGFβ family in...

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PMID: 31326745
DOI: 10.1016/j.scr.2019.101497

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