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Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells

14 Nov 2016

Abstract excerpt

BACKGROUND: Cellular reprogramming is a stressful process, which requires cells to engulf somatic features and produce and maintain stemness machineries. Autophagy is a process to degrade unwanted proteins and is required for the derivation of induced pluripotent stem cells (iPSCs). However, the role of autophagy during iPSC maintenance remains undefined. METHODS: Human iPSCs were investigated by microscopy,...

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PMID: 27846905
DOI: 10.1186/s13287-016-0425-x

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